Stem cells are cells that have the ability to self-renew and differentiate into multiple cell types. They have potential therapeutic and regenerative medicine applications. Stem cells can divide rapidly and replace the functions of senescent somatic cells to maintain the normal functioning of the body.

The relationship between NMN and stem cells lies in the fact that some studies have shown that NMN can promote the proliferation and differentiation of stem cells. By increasing NAD+ levels, NMN can improve the activity of stem cells, thereby promoting their self-renewal and differentiation ability.

What are stem cells

Stem cells are cells that have the ability to self-renew and differentiate into multiple cell types. They are primitive, undifferentiated cells that can differentiate into various types of cells in the body, such as nerve cells, heart cells, muscle cells, etc.

The cycle of cell renewal is different, and some cells (such as intestinal villus cells) only survive for 2-3 days, while bone cells survive for about 10 years. When these cells die, stem cells need to divide new cells to replace these places and carry out the original functions of the cell.

picture

The main purpose of preserving cord blood is to extract hematopoietic stem cells from cord blood, so as to be used for the treatment of leukemia, blood system diseases and other malignant tumors, leaving a guarantee for life and health.

Second, the importance of stem cells

Stem cells play an important role in cell replacement, tissue repair and regeneration, anti-aging, immune regulation and disease treatment. It has the ability of self-renewal, multi-directional differentiation, and originality.

In the process of cell aging and apoptosis in other tissues and organs, a stem cell will rapidly divide into two stem cells, one of which will occupy the position of the original stem cell and perform the original function, while the other stem cell will quickly "run" to change its shape and function to replace the apoptotic cell to perform its original function. It can be said that stem cells are the basis for the proper functioning of our bodies.

At present, the application field of stem cells is also relatively wide:

1. Regenerative medicine: Stem cells can differentiate into various cell types, so they are widely used in regenerative medicine. For example, stem cells can be used to repair or replace damaged tissues and organs such as the heart, liver, bones, nervous system, etc.

2. Disease treatment: Stem cells can be used to treat some difficult or incurable diseases. For example, stem cell transplantation can be used to treat blood system diseases such as leukemia and lymphoma. Stem cell therapy can also be used to treat diabetes, Parkinson's disease, spinal cord injury and other conditions.

3. Drug development: Stem cells can be used for screening and evaluation of drug development to improve the efficiency and accuracy of drug development. By using stem cell models, it is possible to simulate the onset and progression of diseases, thus accelerating the discovery and development of new drugs.

3. NMN and stem cells

With the increase of age, the ability of stem cells to divide will also decrease, and the reactive oxygen species produced by stem cells during the division process will lead to the aging of stem cells and the decline of function. NMN can play the following roles in providing the vitality of stem cells:

1. NMN can restore the vitality of stem cells

Researchers at East China University of Science and Technology have found that NMN can help maintain the functional lifespan of stem cells in a petri dish, thereby improving the effectiveness of stem cell therapy.

2. NMN enhances stem cell migration

Because stem cells are needed to locate the injured tissue site for the treatment to work, the researchers tested the effect of NMN on stem cell migration. In the results of the study, it was shown that NMN increased stem cell migration by three times. These results suggest that NMN can enhance the homing effect of stem cells for use in stem cell therapy.

3. NMN has the ability to resist oxidation and prolong the life span of stem cells

A 2023 study published in Antioxidants found that a substance known as NMN promotes stem cell growth, reduces levels of reactive oxygen species (ROS), and prevents stem cells from entering an aging state (a dysfunctional pro-inflammatory state).

General junction

Stem cells are cells with strong ability to divide and differentiate, which can quickly replace the position of senescent cells in the body and maintain the normal physiological activities of the body. Stem cells have also made significant contributions to the treatment of diseases.

NMN can delay the aging of stem cells by eliminating the number of reactive oxygen species during stem cell division. In addition, NMN can enhance the migration ability of stem cells, enhance the homing effect of stem cells, and be used in stem cell therapy.